CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhIL-15) is associated with expansion of peripheral blood CD56+ NK cells and CD8+ T cells
نویسندگان
چکیده
CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhIL15) is associated with expansion of peripheral blood CD56+ NK cells and CD8+ T cells Chihiro Morishima, Douglas G McNeel, Manish R Patel, Holbrook E Kohrt, Thomas A Waldmann, John A Thompson, Kevin C Conlon, Paul M Sondel, Heather A Wakelee, Minjun C Apodaca, Steven P Fling, Mary L Disis, Stephen P Creekmore, Jeffrey S Miller
منابع مشابه
CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhil-15) is associated with robust expansion of peripheral blood CD56+ NK cells
Background IL-15 activates and induces the proliferation of CD8+ T cells and NK cells. The Cancer Immunotherapy Trials Network (CITN) is conducting a Phase I, open-label, dose-escalation study of subcutaneous (SQ) rhIL-15 in advanced melanoma, renal cell, non-small cell lung and squamous cell head and neck carcinoma patients. The primary objective is to determine the maximum tolerated dose; sec...
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Natural Killer (NK) cells are the main lymphocyte population expressing P75 B chain of the IL-2 receptor (IL-2R). Consequently, incubation of peripheral blood lymphocytes with IL-2 induce selective activation of NK cells and results in NK activity and generation of Lymphokine activated killer (LAK) cells activity and proliferation. One of the early events during IL-2 activation of peripheral bl...
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IL-15 promotes activation and maintenance of natural killer (NK) and CD8(+) T effector memory (T(EM)) cells, making it a potential immunotherapeutic agent for the treatment of cancer and immunodeficiency states. Here we report the immunologic effects of 3 different IL-15 dosing strategies in Rhesus macaques. IL-15 at a dose of 20 μg/kg/d administered by continuous intravenous infusion for 10 da...
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Background and purpose: The aim of this study was to compare the proportion of natural killer (NK) and natural killer T (NKT)-like cells in dyspeptic disorders caused by Helicobacter pylori (H. pylori). Materials and methods: In a case-control study, 27 patients with gastric cancer (GC), 25 patients with peptic ulcer (PUD), and 22 patients with non-ulcer dyspepsia (NUD) were enrolled. After en...
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PURPOSE The purpose is to determine the immunological effects of recombinant human interleukin (rhIL)-12 therapy after autologous stem cell transplantation. EXPERIMENTAL DESIGN Twelve patients (8 non-Hodgkin's lymphoma, 2 Hodgkin's disease, and 2 plasma cell myeloma) were treated with rhIL-12 by bolus i.v. injection in doses of 30, 100, or 250 ng/kg starting at a median of 66 days posttranspl...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015